3 dead in West Side crash

Officials examine a Jeep Cherokee that crashed and left three critically injured near 31st Street and Western Avenue. (Nuccio DiNuzzo, Chicago Tribune / February 5, 2013)

By Ellen Jean Hirst and Liam Ford




Tribune reporters

12:58 a.m. CST, February 6, 2013

A man and two women died in a crash on the city's West Side, authorities said.

Firefighters were called to the accident near 31st Street and Western Avenue about 8:30 p.m., according to the department's media office.

Fire officials cut three people out of a red Jeep after the car lost control and somehow ended up on it's top just west of Western Avenue on 31st Street, police  said.

Three people had been riding in the SUV and all were taken to Mount Sinai Hospital and pronounced dead there, police said. They were the only occupants in the SUV.

Just before 10 p.m., the radio in the SUV -- which was flipped on its top -- could still be heard faintly from a distance.

The SUV was eastbound on 31st Street when it hit a curb, then a light pole, and ended up on its roof, Chicago Police News Affairs Officer Hector Alfaro said.

"Some of the damage is from the fire department," police said of the doors, which had been cut to free the car's occupants. "But they flipped the car themselves.

Investigators from the department's Major Accidents Investigations Unit arrived at the scene Thursday night to investigate what had happened.

Three people were taken to Mount Sinai Hospital, one in "extremely critical" condition, two in critical condtion, according to the fire department. A spokesman at the Cook County medical examiner's office confirmed the deaths.

Video from the scene showed a red Jeep flipped over, with its roof crushed, and a person wrapped in black on a stretcher being taken into an ambulance.

chicagobreaking@tribune.com

Twitter: @ChicagoBreaking

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Well: Getting Into Your Exercise Groove

Phys Ed

Gretchen Reynolds on the science of fitness.

This isn’t meant as an insult, but you are physiologically lazy. So am I. So are we all. Using treadmill testing, scientists have definitively established that, like other animals, humans naturally aim to use as little energy as possible during most movement. So when we walk or run, our bodies tend to choose a particular cadence, a combination of step length and step frequency, that allows us to move at any given speed with as little physiological effort as possible.

How we pick that cadence, though, and whether we can or would even want to change it has been unclear. But a series of recent studies involving runners, walkers, metronomes and virtual reality curtains suggests that while the tug of physiological laziness is strong, it can be controlled, or at least tweaked, with some conscious effort — and perhaps your iPhone playlist.

In the first and most revelatory of the studies, physiologists at Simon Fraser University in British Columbia asked adult volunteers to walk on a treadmill at an easy pace. Using motion capture technology, the scientists determined how many steps each person was taking per minute at this speed. A person’s pace depends, of course, on both step length and step frequency. But because the two are inextricably entwined — lengthen your stride and you’ll take fewer steps over a given distance — studying one provides sufficient information about the other, and frequency is easier to enumerate.

After establishing each volunteer’s preferred step frequency, the scientists then sped up or slowed the treadmill, and the researchers measured how quickly people’s legs responded.

The body, remember, wants things to be easy. When you increase or decrease the speed of your walking or running, various physiological changes occur; the amount of oxygen in your blood rises or falls, for instance, because your muscles start requiring more or less of the stuff. Other biochemical changes also occur within muscle cells. Sensing those changes, the body realizes that, at this new speed, your cadence isn’t ideal; you’re taking too few or too many steps to use the least possible amount of energy. Your body adjusts.

But that process takes a little while, at least five seconds or so for the oxygen levels to change and your body to recognize the alteration, says Max Donelan, a professor at Simon Fraser University who was a co-author of the study with his graduate student Mark Snaterse and others.

However, the walkers in the study were adjusting their step frequency within less than two seconds after the treadmill speed changed, Dr. Donelan points out. They then fine-tuned their pacing after that. But the first adjustment came almost instantly.

The same process occurred when the researchers repeated the experiment with runners. If the treadmill speed changed, the runners’ step frequency shifted almost immediately, too fast for internal physiology to have played much of a role.

These insty adjustments suggest that our brains very likely contain huge libraries of preset paces, Dr. Donelan and his colleagues have concluded, of idealized, “physiologically efficient” step cadences for any given speed and condition. It seems probable, in fact, that over our lifetimes, Dr. Donelan says, our brains develop and store countless templates for most pacing situations. We learn and remember what cadence allows us to use the least energy at that speed, and when we reach that speed, we immediately default to our body’s most efficient pace.

Just how the brain recognizes that we are moving at any particular speed is not completely understood, Dr. Donelan says, but almost surely involves messages from the eyes, feet, ears, nervous system, skin and other bodily systems.

Interestingly, it seems to be quite difficult to fool your brain. When Dr. Donelan and his colleagues draped shower-curtain-like enclosures around the front of a treadmill, projected a virtual reality scene of a hallway onto it and then manipulated people’s sense of the speed with which they were moving through the hallway, they found that people’s step frequency would quickly change to match this supposed new speed. But then they would settle back into their former cadence, even as the virtual hallway continued to move past them at unnatural speed.

Visual cues simply were not strong enough to affect pacing for long.

But the scientists have found one signal that does seem effectively to override the body’s strong pull toward its preferred ways of moving: a strongly rhythmic beat. When Dr. Donelan and his colleagues fitted runners or walkers with headphones tuned to a metronome, they found that they could increase or decrease volunteers’ step frequency, even if that frequency was faster or slower than a person’s preferred step pattern. They would also maintain that pace for as long as the metronomic rhythm continued unaltered. The volunteers aligned their movement to the beat.

In practical terms, this finding suggests that music may be one of the best ways to affect the pace of your running or walking, especially if you are trying to maintain a pace with which you are not familiar or which feels awkward. Want to start jogging faster than you have in the past? Load your iPod with uptempo music, Dr. Donelan suggests (although obviously ease into any changes in training slowly, to lessen the risk of injuries).

Dr. Donelan and his colleagues even have recently launched an iPhone app called Cruise Control that allows people to coordinate their pacing with their playlists. Input your preferred running or walking speed and the app skims your music library (nonjudgmentally; if you like Nickelback, that’s your business) and strings together songs with the requisite beat, even subtly altering the tempo of songs, if needed.

But of course, if you’re comfortable with your pace as it is, stick with it. For me, the most stirring message of these recent experiments is that, left to its own devices, your body will almost always obligingly try to choose the least demanding pace for you, a goal with which I’m happy to fall into step.

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Chicago sees surge in foreclosure auctions

More than 35,000 homes and small multifamily buildings in the Chicago area completed the foreclosure process last year, the highest number since the housing crisis began, and the vast majority of them became bank-owned.

An increase in foreclosure auctions was expected since lenders shelved many foreclosure cases while state and federal authorities investigated allegations of faulty foreclosure processes. Still, the heightened level of auctions — 35,244 in 2012, compared with 20,281 in 2011 — along with an increase in initial foreclosure filings, shows the local housing market has a long road to recovery, according to the Woodstock Institute.

"There's going to be pain in the housing market in the short term," said Katie Buitrago, senior policy and communications associate at Woodstock. "There's still high levels of filings. Five years into it, there is still work to be done to help people save their homes."

The Chicago-based public policy and research group is expected to release its report on 2012 foreclosure activity Wednesday.

The year-end numbers show that, with few exceptions, all Chicago neighborhoods and suburban communities saw high double-digit percentage gains in auctions last year. Across the six-county area, 91.3 percent of the foreclosed properties were repossessed by lenders. At the same time, notices of initial default sent to homeowners, the first step in the foreclosure process, increased by 2.9 percent last year, to 66,783.

Real estate agents have worried for more than two years about a glut of foreclosed properties — a shadow inventory — that banks would list for sale en masse and cause home values to plunge. That largely has not happened, but the vast number of distressed properties in the market has kept a lid on local home values.

On Tuesday, for instance, Fannie Mae and Freddie Mac's websites listed 2,415 Cook County homes for sale that the two agencies had repossessed.

Chicago-area home prices, including distressed sales, fell 2.3 percent in December from a year ago, housing analytics firm CoreLogic said Tuesday. Illinois was one of only four states to see home-price depreciation.

The increase in auctions "is a mixed blessing," Buitrago said. "We've been having a lot of trouble in the region with vacant properties that have been languishing for years. The longer they're vacant, the more likely they are to be a destabilizing force in their communities."

Woodstock found that within the city of Chicago, there were 20 communities where more than 1 in 10 owner-occupied one- to four-unit residential buildings and condos went through foreclosure from 2008 to 2012. Five of those neighborhoods are included in the city's 18-month-old Micro-Market Recovery Program, a coordinated effort to stabilize neighborhoods and property values hit hard by foreclosures and vacant buildings.

Also designed to benefit hard-hit areas are the recent establishment of a Cook County Land Bank and legislation waiting for Gov. Pat Quinn's signature that will fast-track the foreclosure process for vacant, abandoned homes while providing financial resources to foreclosure prevention efforts.

mepodmolik@tribune.com

Twitter @mepodmolik

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Chicago, your commute will likely take far longer than you think

You can predict with a high degree of confidence that the time it takes to drive from Point A to B on any given day is unpredictable.

And it's not just snowy or rainy days. It can be any day.

If there is a bright side, it's that Chicago was not the worst.

Residents of the Chicago area are accommodating that increasing uncertainty by setting aside more time each day — just in case — for the commute, new research shows.

For the most important trips, such as going to work, medical appointments, the airport or making a 5:30 p.m. pickup at the child care center to avoid late fees, drivers in northeastern Illinois and northwest Indiana should count on allotting four times as much time as it would take to travel in free-flowing traffic, according to the "Urban Mobility Report" to be released Tuesday by the Texas A&M Transportation Institute. The analysis is based on 2011 data, which are the most recent available.

It is the first time that travel reliability was measured in the 30-year history of the annual report. The researchers created a Planning Time Index geared toward helping commuters reach their destinations on time in more than 95 percent of the trips. A second index, requiring less padding of travel time, would get an employee to work on time four out of five days a week.

"If you plan only for average traffic conditions on your trip in the Chicago area, you are going to be late at least half the time," said Bill Eisele, a senior research engineer at the Transportation Institute who co-authored the study.

The constant unreliability that hovers over commuting is stealing precious time from other activities, crimping lifestyles, causing mounting frustration for drivers and slapping extra costs on businesses that rely on just-in-time shipments to manage inventory efficiently, researchers found.

The Chicago region ranked No. 7 among very large urban areas and 13th among 498 U.S. cities on a scale of the most unreliable highway travel times. The Washington area was the worst. A driver using the freeway system in the nation's capital and surrounding suburbs should budget almost three hours to complete a high-priority trip that would take only 30 minutes in light traffic, the study said.

The Washington area was followed on the list by the metropolitan areas of Los Angeles, New York-Newark, Boston, Dallas-Fort Worth, and Seattle.

Rounding out the top 10, the Chicago metro area was trailed by San Francisco-Oakland, Atlanta, and Houston.

Truck driver Frank Denk said he usually adds an hour or two to his trip through the Chicago area. Sometimes, it's not enough, other times traffic isn't a problem, he said. The one constant, Denk said Monday afternoon while taking a break at the O'Hare Oasis on the Tri-State Tollway, is that it is almost impossible to anticipate correctly.

"Job-wise, it can be very detrimental to truckers," said Denk, who is based in Green Bay, Wis. "All of a sudden, you're not able to make your delivery."

But quadrupling the time to travel back and forth each day? That's excessive, said Mike Hennigan, a 64-year-old accountant who regularly commutes from his Evanston home to his office near the junction of the Kennedy and Edens expressways. He recommends doubling the anticipated travel time.

"I can predict when it's going to be bad," Hennigan said, although he is less optimistic about his travel times when he heads toward downtown.

"Coming into the Loop can be deadly, especially later in the week," Hennigan said.

Overall, traffic congestion in the Chicago region is getting worse as the economy improves, although it's not as severe as the grip that gridlock has taken recently on some other very large metropolitan areas in the U.S., according to the report. The Washington area again topped the list, followed by Los Angeles, San Francisco-Oakland, New York-Newark, Boston, Houston, Atlanta, Chicago, Philadelphia, and Seattle.

No longer being ranked at the very top of the congestion heap provides little consolation for Chicago-area drivers.

What should be a 20-minute jaunt across town in Chicago or the suburbs if highway capacity were sufficient to permit vehicles to travel the speed limit now becomes about an 80-minute ordeal, according to the Texas A&M study. Scheduling 80 minutes for the trip would ensure an on-time arrival 19 out of 20 times, the study concluded.

But that would be similar to treating every day of the year as if it were like Monday, when a moderate snowfall blanketing the Chicago region smacked traffic into slow motion during the morning rush.

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Well: Expressing the Inexpressible

When Kyle Potvin learned she had breast cancer at the age of 41, she tracked the details of her illness and treatment in a journal. But when it came to grappling with issues of mortality, fear and hope, she found that her best outlet was poetry.

How I feared chemo, afraid
It would change me.
It did.
Something dissolved inside me.
Tears began a slow drip;
I cried at the news story
Of a lost boy found in the woods …
At the surprising beauty
Of a bright leaf falling
Like the last strand of hair from my head

Ms. Potvin, now 47 and living in Derry, N.H., recently published “Sound Travels on Water” (Finishing Line Press), a collection of poems about her experience with cancer. And she has organized the Prickly Pear Poetry Project, a series of workshops for cancer patients.

“The creative process can be really healing,” Ms. Potvin said in an interview. “Loss, mortality and even hopefulness were on my mind, and I found that through writing poetry I was able to express some of those concepts in a way that helped me process what I was thinking.”

In April, the National Association for Poetry Therapy, whose members include both medical doctors and therapists, is to hold a conference in Chicago with sessions on using poetry to manage pain and to help adolescents cope with bullying. And this spring, Tasora Books will publish “The Cancer Poetry Project 2,” an anthology of poems written by patients and their loved ones.

Dr. Rafael Campo, an associate professor of medicine at Harvard, says he uses poetry in his practice, offering therapy groups and including poems with the medical forms and educational materials he gives his patients.

“It’s always striking to me how they want to talk about the poems the next time we meet and not the other stuff I give them,” he said. “It’s such a visceral mode of expression. When our bodies betray us in such a profound way, it can be all the more powerful for patients to really use the rhythms of poetry to make sense of what is happening in their bodies.”

On return visits, Dr. Campo’s patients often begin by discussing a poem he gave them — for example, “At the Cancer Clinic,” by Ted Kooser, from his collection “Delights & Shadows” (Copper Canyon Press, 2004), about a nurse holding the door for a slow-moving patient.

How patient she is in the crisp white sails
of her clothes. The sick woman
peers from under her funny knit cap
to watch each foot swing scuffing forward
and take its turn under her weight.
There is no restlessness or impatience
or anger anywhere in sight. Grace
fills the clean mold of this moment
and all the shuffling magazines grow still.

In Ms. Potvin’s case, poems related to her illness were often spurred by mundane moments, like seeing a neighbor out for a nightly walk. Here is “Tumor”:

My neighbor walks
For miles each night.
A mantra drives her, I imagine
As my boys’ chant did
The summer of my own illness:
“Push, Mommy, push.”
Urging me to wind my sore feet
Winch-like on a rented bike
To inch us home.
I couldn’t stop;
Couldn’t leave us
Miles from the end.

Karin Miller, 48, of Minneapolis, turned to poetry 15 years ago when her husband developed testicular cancer at the same time she was pregnant with their first child.

Her husband has since recovered, and Ms. Miller has reviewed thousands of poems by cancer patients and their loved ones to create the “Cancer Poetry Project” anthologies. One poem is “Hymn to a Lost Breast,” by Bonnie Maurer.

Oh let it fly
let it fling
let it flip like a pancake in the air
let it sing: what is the song
of one breast flapping?

Another is “Barn Wish” by Kim Knedler Hewett.

I sit where you can’t see me
Listening to the rustle of papers and pills in the other room,
Wondering if you can hear them.
Let’s go back to the barn, I whisper.
Let’s turn on the TV and watch the Bengals lose.
Let’s eat Bill’s Doughnuts and drink Pepsi.
Anything but this.

Ms. Miller has asked many of her poets to explain why they find poetry healing. “They say it’s the thing that lets them get to the core of how they are feeling,” she said. “It’s the simplicity of poetry, the bare bones of it, that helps them deal with their fears.”

---

Have you written a poem about cancer? Please share them with us in the comments section below.

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Boeing asks FAA to allow Dreamliner test flights

Aerospace giant Boeing Co. has asked the Federal Aviation Administration to let it begin test flights on its grounded 787 Dreamliner passenger jet.

The new plane has been grounded since Jan. 16 by the FAA because of numerous incidents and high-profile fires involving the onboard lithium-ion batteries. Investigators around the world are looking into the matter.

The company disclosed its request for in-flight testing Monday in an email.

“Boeing has submitted an application to conduct test flights, and it is currently under evaluation by the FAA,” said Marc Birtel, a company spokesman, who would not comment further.

The FAA is reportedly looking into Boeing request, but would not comment.

The 787's battery systems were called into question Jan. 7 when a smoldering fire was discovered on the underbelly of a Dreamliner in Boston operated by Japan Airlines after the 183 passengers and 11 crew members had deplaned at the gate.

The National Transportation Safety Board is examining what went wrong. On Friday, the NTSB released its seventh update on the investigation into the lithium-ion battery systems. It said it has begun CT scanning the battery cells to examine their internal condition.

In addition, the NTSB disclosed that a battery expert from the Department of Energy joined the investigative team to lend additional expertise to ongoing testing.

In a separate incident Jan. 16 involving a 787 operated by All Nippon Airways in southwestern Japan, smoke was seen swirling from the right side of the cockpit after an emergency landing related to the plane's electrical systems. All 137 passengers and crew members were evacuated from the aircraft and slid down the 787's emergency slides.

The Japan Transport Safety Board, the country's version of the NTSB, is heading the investigation into All Nippon's emergency landing and reported fire.

No passengers or crew members were reported injured in the incidents. But the recent events have become a public relations nightmare for Boeing, which has long heralded the Dreamliner as a forerunner of 21st century air travel.

The 787, a twin-aisle aircraft that can seat 210 to 290 passengers, is the first large commercial jet with more than half its structure made of composite materials rather than aluminum sheets. It's also the first large commercial aircraft that extensively uses electrically powered systems involving lithium-ion batteries.

Boeing's lithium-ion batteries are made in Japan by Kyoto-based GS Yuasa Corp.

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Ravens stave off 49ers' rally to win Super Bowl 34-31

NEW ORLEANS – The Ravens were almost done in Sunday by a reign delay.

A power outage at the Superdome halted Super Bowl XLVII for 34 minutes casting the stadium into a twilight-like darkness and allowing the reeling 49ers to regroup with almost a full half remaining.

Despite an impressive power surge by the 49ers, however, the Ravens were able to hang on for a 34-31 victory, hoisting the Lombardi Trophy for the second time in their history.

"It's never pretty, it's never perfect, but it's us," said Ravens coach John Harbaugh, whose team had lost four of its last five regular-season games before going on a marvelous run that included knocking off the Colts, Broncos and Patriots to reach the biggest stage.

Even before the ball was kicked off, the game made history. For the first time, brothers stood on opposite sidelines as head coaches. John's younger brother, Jim, coaches the 49ers, making Sunday's victory somewhat bittersweet for the Ravens coach.

"It's tough," John said. "It's very tough. It's a lot tougher than I thought it was going to be. It's very painful."

Most excruciating for the 49ers was how close they came. The game essentially ended on a goal-line stand, with three incomplete passes by the 49ers from the Ravens' 5 inside the final two minutes.

Second-year quarterback Colin Kaepernick, who showed incredible poise for a player with just 10 career starts, failed to connect with Michael Crabtree on three straight tries. On the last, Jim Harbaugh complained angrily that cornerback Jimmy Smith had held Crabtree, but officials were unsympathetic.

"There's no question in my mind that there was a pass interference and then a hold on Crabtree on the last one," the 49ers coach said.

The 49ers are now 5-1 in Super Bowls. By winning, the Ravens improved to 2-0 in the marquee game, becoming the only NFL team with multiple Super Bowl wins and an unblemished record in the big game.

"Lord knows, this season, it was tough, it was rough, I'm just ready to kick my feet up," said an effusive Ravens safety Ed Reed, a New Orleans native who said he felt like leading a parade "all the way up Poydras," the street that runs past the Superdome.

Reed intercepted an overthrown Kaepernick pass in the first half and grabbed a piece of history. It was the first time a 49ers quarterback had been picked off in the Super Bowl, with Joe Montana and Steve Young accounting for 17 touchdown passes in the previous five appearances.

Kaepernick completed 16 of 28 for 302 yards, with a touchdown and an interception. He also ran seven times for 62 yards and a score.

The star quarterback Sunday was Ravens quarterback Joe Flacco, who threw three touchdown passes and was named the game's most valuable player.

"I think we gave the country a pretty good game to watch — not to our liking necessarily — but that's the way it goes sometimes, and that's the way we do things," said Flacco, who completed 22 of 33 for 287 yards with a passer rating of 124.2.

The game was a masterpiece for the Ravens' Jacoby Jones, who grew up in New Orleans.

First, he had a 56-yard touchdown in the second quarter that had to have countless fans rewinding their DVRs. He slipped past cornerback Chris Culliver and caught a slightly underthrown bomb, turning with his back to the goal line to grab the ball, then falling to the ground. Untouched, he immediately popped to his feet, spun away from a defender, then beat Culliver again to the end zone.

That was just one of Culliver's travails on a very bad night for the young corner, who found himself in hot water earlier in the week when he said on a radio show that he would never accept a gay teammate.

Keeping up with Jones wasn't an option, not after he took the opening kickoff of the second half and returned it 108 yards for a touchdown, setting a Super Bowl record and tying the NFL record. Jones' return took a mere 11 seconds. Not bad for a guy in pads who had to dodge defenders along the way.

Before most of the lights ringing the field went out, the Ravens had built a 28-6 lead. But after the delay, during which players stretched in the surreal half-light, the 49ers answered with a 23-3 run.

With their red-and-gold-clad fans roaring their approval, the 49ers just missed a chance to forge a tie at 31 with 10:04 remaining, after Kaepernick ran for a 15-yard touchdown, the longest scoring run by a quarterback in Super Bowl history. But his conversion pass to Randy Moss was incomplete, however, leaving the Ravens to cling to a tenuous two-point lead.

The 49ers wouldn't score on offense again, and their only points came on an intentional safety by the Ravens in the game's final moments.

The game was a curtain-dropper for All-Pro Ravens linebacker Ray Lewis, who punctuated his career the way NFL stars John Elway, Jerome Bettis and Michael Strahan did — with a championship ring.

For the Ravens, the night was unforgettable.

Asked what he told his team before the game, John Harbaugh said: "I told them there's an old Motown song that says, 'There ain't no mountain high enough, ain't no valley low enough, ain't no river wide enough to keep us from winning this championship.' That's exactly what I said. It's a great song too."

Reed had another ditty in mind.

The All-Pro safety, having collected the crowning achievement of his storied career, cleared his throat, leaned into his microphone and crooned: "I've got two tickets to paradise …"

It was that kind of night.

sfarmer@tribune.com

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Is it game over for Nintendo?

The Wii U is a bust (so far). And the legendary gaming company’s future is looking increasingly bleak

Nintendo had no choice but to go all in with the Wii U, the newest in a long line of ostensibly childhood-defining game consoles. Unfortunately, the company also inherited the weighty expectations of the original Wii — which, if you’ll remember, became a surprise hit when it debuted in 2006, or just two short years after the world was first introduced to a little-known senator named Barack Obama. But ever since the Wii U hit store shelves last November, sales have been disappointing. Now the company is dramatically lowering its forecasts for the future. 

Initial sales figures indicate that Nintendo has so far sold just 3.06 million Wii U game consoles, and anticipates moving just four million Wii U units through March — far below previous estimates of 5.5 million, predictions that weren’t even that optimistic to begin with. 

Initial reviews of the Wii U were mixed. Yes, it’s fun. But the console failed to offer a compelling reason for consumers to free up dusty shelf space alongside their Xbox 360s or PlayStation 3s. Some critics say the console is confused, and Nintendo didn’t know if it was targeting mature gamers fixated on first-person shooter games like Call of Duty and Borderlands, or more casual fans like the original Wii did with its motion-sensing nunchuck. Further complicating matters is a nimble new mobile industry, dominated by non-committal, take-anywhere games like Temple Run and Angry Birds. 

“Nintendo needs a change in strategy,” Michael Pachter, a gaming research analyst for Wedbush Securities, tells The New York Times. Even though Nintendo is an instantly recognizable brand the world over, the company still doesn’t license its gaming titles for other platforms (ever see Mario on an iPhone?). To make matters worse, on Thursday, Nintendo president Satoru Iwata said that the company has no intention of lowering the price of its $ 300 flagship gaming system anytime soon. “We were already offering it at a good price,” he said. 

That means Nintendo, unless it releases a best-selling breakout title soon (Zelda, perhaps? Super Smash Bros. Brawl?), will continue on its path toward an increasingly dark future. The company already had its worst year ever in 2011. Dramatic restructuring seems imminent.

Consoles — compared to phones, tablets, laptops, and many other gadgets — have a much slower product cycle. Manufacturers only press “reset” every couple of years so that game-makers aren’t constantly readjusting to new hardware.

For quickly aging dinosaurs like Nintendo, that means more plodding along. More disappointing forecasts. More reluctant critics. More lost opportunities to earn the trust of lifelong fans. More, more, more. (Or for Nintendo, less, less, less?)

“People have to try it to see it is fun,” Iwata said of the Wii U. Undoubtedly, it is.

But unfortunately for Nintendo, “fun” just isn’t good enough anymore.

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The top films at the North American Box Office

LOS ANGELES (Reuters) – Following are the top 10 movies at North American box offices for the weekend starting February 1, led by Warm Bodies at No. 1, according to studio estimates compiled by Reuters. 1 (*) Warm Bodies…………………………..$ 20.0 million 2 (1) Hansel and Gretel……………………..$ 9.2 million 3 (3) Silver Linings Playbook………………..$ 8.1 million 4 (2) Mama…………………………………$ 6.7 million 5 (4) Zero Dark Thirty………………………$ 5.3 million 6 (*) Bullet to the Head…………………….$ 4.5 million 7 (5) Parker……………………………….$ 3.2 million 8 (6) Django Unchained………………………$ 3.0 million 9 (10)Les Miserables………………………..$ 2.4 million 10 (11)Lincoln………………………………$ 2.4 million NOTES: (*) = new release

CUMULATIVE TOTALS: Lincoln…………………………………..$ 170.8 million Django Unchained…………………………..$ 151.0 million Les Miserables…………………………….$ 141.5 million Silver Linings Playbook…………………….$ 80.4 million Zero Dark Thirty…………………………..$ 77.8 million Mama……………………………………..$ 58.3 million Hansel and Gretel: Witch Hunters…………….$ 34.5 million Warm Bodies……………………………….$ 20.0 million Parker……………………………………$ 12.4 million Bullet to the Head…………………………$ 4.5 million

“Hansel & Gretel: Witch Hunters” was distributed by Paramount Pictures, a unit of Viacom Inc. “Zero Dark Thirty” was released by Sony Corp’s movie studio. “Warm Bodies” and “The Last Stand” were distributed by Lions Gate Entertainment. “Bullet to the Head” was released by Warner Bros, a unit of Time Warner Inc “Django Unchained” and “Silver Linings Playbook” were distributed by Weinstein Co. “Les Miserables” and “Mama” were distributed by Universal Pictures, a unit of Comcast Corp.

(Reporting By Ronald Grover and Andrea Burzynski; Editing by Sandra Maler)

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Medicines Co. Licenses Rights to Cholesterol Drug

The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.

The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.

That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.

The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.

ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.

Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.

But that has yet to be proved. No drug using RNA interference has reached the market.

The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.

Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.

The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.

“It’s a bit like getting the band back together,” Dr. Maraganore said.

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